NAD+ availability
Lower NAD+ levels have been observed in some older tissues. The pattern varies by tissue, health and activity.
A changing metabolic resource
FREE NMN + MAGNESIUM SAMPLES
Free
A little something extra with every November order.
YOUR AM RITUAL
Advanced Liposomal NMN
Cellular support, from within.*
500 mg Liposomal NMN with 100 mg Liposomal CoQ10 and 1 mg Spermidine. Three purposeful ingredients built around NAD+ metabolism, cellular energy and everyday cellular support.
500 mgLiposomal NMNNAD+ metabolism*
100 mgLiposomal CoQ10Cellular energy*
1 mgSpermidineCellular maintenance*
Third-party tested
Cryo-TEM Verified
Made In Korea
Choose your format
One-time prices30-day money-back guarantee
On eligible first orders. See terms.
Complete your ritual.
Everyday hydration.
Start with a sample.
Explore taste and mixability.
Understand the change
As we age,
our cells change.
NAD+ helps cells turn nutrients into usable energy. Studies have found lower NAD+ levels in some tissues in older adults; one part of a broader picture of cellular aging.
NAD+ & cellular agingThe biological picture
Energy production
NAD+ helps shuttle electrons in energy metabolism. Mitochondrial function can also change with age.
The machinery behind cellular energy
Cellular upkeep
NAD+-dependent enzymes participate in cellular maintenance. Aging also involves changes in how cells recycle and maintain components.
Maintenance is part of the picture
Age-related NAD+ changes are tissue-specific; whole-blood levels do not consistently decline.
Human muscle study ↗
Whole-blood study ↗
Why We Created Advanced Liposomal NMN
The biology informs
the formula.
Three ingredients. Three complementary roles: NAD+ metabolism, cellular energy and maintenance. Explore the function behind each choice.
Liposomal NMN
NAD+ metabolism.
Meet the precursor.
NMN is a precursor the body can use to make NAD+, a coenzyme involved in cellular energy metabolism.
From biology to formulationThe connection: NAD+ availability. NMN provides a precursor used in NAD+ synthesis; this does not establish restoration of youthful tissue levels.
Liposomal CoQ10
Cellular energy.
A complementary role.
CoQ10 is naturally present in the body and participates in the processes cells use to produce energy.
Why it belongsCoQ10 participates in the mitochondrial electron transport chain, complementing the NAD+ precursor role of NMN.
Spermidine
Cellular upkeep.
Part of the thinking.
Spermidine is a naturally occurring polyamine involved in normal cellular processes, including cellular maintenance.
Why it belongsIncluded from rice germ extract for its biological role; the amount is not a claim of proven autophagy enhancement in people.
ab:MAX™ Liposomal Technology
Thoughtfully formulated.
Down to the delivery.
The formula uses ab:MAX™ liposomal NMN and CoQ10. Liposomes are lipid-based structures used in ingredient delivery.
Why it belongsDelivery is part of the formulation design. This is not a claim of proven absorption for the finished NMN formula.
Amounts shown per daily sachet. Selected ingredients shown; see the product label for the complete formula.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
The evidence behind your ritual
Healthy aging, studied.
INTRACELLULAR NAD+ · BLOOD IMMUNE CELLS
Cellular NAD+, measured.
Researchers measured NAD+ inside peripheral blood mononuclear cells (PBMCs), which are immune cells collected from blood. Mean NAD+ content increased over eight weeks of NMN supplementation. These are intracellular measurements, not skeletal-muscle or mitochondrial NAD+ measurements.
250 mg NMN daily · 8 weeks · 9 completing participants
See study details
An eight-week, single-arm, open-label study in healthy middle-aged Japanese men. Participants completed an earlier placebo period, but there was no simultaneous randomized placebo control during NMN treatment. Nine participants completed the trial. PBMC NAD+ levels increased from 25.48 to 41.43 pmol/mg wet cells (p=0.0046 for Week 0 vs. Week 8).
The values are means of an intracellular biomarker, not measurements of energy, physical performance, or mitochondrial function.
Read the full studySource: Yamaguchi et al., Endocrine Journal, 2024, Table 2.
Open-label single-arm study; no concurrent randomized placebo group. The results do not establish improvements in muscle function, physical stamina, or aging rate. Study formulations and doses differ from Haroutine Advanced Liposomal NMN (500 mg NMN plus other actives). These are ingredient research findings, not clinical results for the finished Haroutine product.
BLOOD-CELL NAD+ · HUMAN RESEARCH
NAD+ inside blood cells, studied.
Researchers measured NAD+ inside peripheral blood mononuclear cells, a group of immune cells.
After 10 weeks of NMN supplementation, resting NAD+ levels in these cells increased. The placebo group showed no significant change.
250 mg NMN daily · 10 weeks · 25 participants completed
See study details
This randomized, double-blind trial included postmenopausal women with prediabetes who were overweight or obese. Thirteen received NMN and 12 received placebo.
The higher four-hour NAD+ exposure reflected higher resting blood-cell levels, not a further rise after the final dose. Muscle NAD+ concentration did not increase.
Read the full studyNAD+ IN BLOOD CELLS10 Weeks
+43%
Higher four-hour NAD+ exposure in blood immune cells compared with placebo, measured after supplementation at the end of 10 weeks. This reflects the area under the measurement curve, rather than a 43% increase from baseline.
Yoshino et al., Science, 202
Findings concern specific blood immune cells, not all body tissues. This trial tested NMN ingredient supplementation, not the finished Haroutine formula.
FUNCTIONAL PERFORMANCE · SIX-MINUTE WALK TEST
Walking endurance, studied.
Researchers measured how far adults could walk in six minutes on a manual treadmill. In the 600 mg NMN group, mean walking distance increased from 289 meters at baseline to 435 meters at Day 60. This is a physical-performance measurement, not a direct measurement of mitochondrial energy production.
600 mg NMN daily · 60 days · 20 participants per group
See study details
A multicenter, randomized, double-blind, placebo-controlled study of 80 healthy adults ages 40–65. Twenty participants received 600 mg NMN daily and 20 received placebo; additional groups received 300 and 900 mg. Walking distance was measured at baseline, Day 30 and Day 60. The study reported significant between-group improvements in the change in walking distance. Baseline means differed between groups.
Read the full studySource: Yi et al., GeroScience, 2023, Table 2.
Randomized trial, n=20 in the 600 mg arm. Walking was a secondary outcome. Other trials, including Igarashi et al., 2026, reported no significant benefit for physical performance. Study formulations and doses differ from Haroutine Advanced Liposomal NMN (500 mg NMN plus other actives). These are ingredient research findings, not clinical results for the finished Haroutine product.
MUSCLE INSULIN SENSITIVITY
How muscle responds to insulin, studied.
In a small randomized trial, researchers studied postmenopausal women with prediabetes who were overweight or obese.
After 10 weeks of NMN supplementation, insulin-stimulated glucose disposal—a measure of muscle insulin sensitivity—was approximately 25% higher than baseline. The placebo group showed no significant change.
250 mg NMN daily · 10 weeks · 25 participants completed
See study details
Researchers conducted a randomized, double-blind, placebo-controlled trial in postmenopausal women with prediabetes who were overweight or obese. Twenty-five participants completed the study: 13 received 250 mg NMN daily and 12 received placebo for 10 weeks.
Muscle insulin sensitivity was assessed before and after treatment using a controlled insulin-infusion test called a hyperinsulinemic-euglycemic clamp. This measures how effectively the body disposes of glucose in response to insulin.
Insulin-stimulated glucose disposal increased by approximately 25% from baseline in the NMN group. The placebo group showed no significant change. The study did not find improvements in muscle mitochondrial oxidative capacity or measured physical function.
Read the full studyMUSCLE INSULIN SENSITIVITY10 weeks
+25%
After 10 weeks, that rate was about 25% higher than the NMN group’s own starting level. It measures muscle insulin sensitivity, how responsive muscle is to insulin.
Yoshino et al., Science, 2021
Figure 2A. Randomized, double-blind, placebo-controlled trial; 25 participants completed. The approximately 25% increase represents change from baseline within the NMN group—not a 25% improvement over placebo. This finding concerns muscle insulin sensitivity, not increased energy, strength, or muscle NAD+ levels. Results apply to the population, dose and formulation studied. The trial tested 250 mg/day NMN.
Inside your formula
Every ingredient.
A clear purpose.
The amount, the role and why it's here. Open an ingredient to look closer.
500 mg Liposomal NMN NAD+ support
NMN gives your body a precursor it can use to make NAD+, a coenzyme involved in everyday cellular function.*
What liposomal means
A phospholipid-based delivery design.
100 mg Liposomal CoQ10 Mitochondrial energy support
CoQ10 supports the processes your cells use to produce energy throughout the day.*
1 mg Spermidine Cellular maintenance
Spermidine is included for its role in normal cellular-maintenance processes.
See Label Niacinamide + B complex See Supplement Facts
Complementary ingredients that support NAD+ metabolism and the pathways your cells use to produce energy.*
53 mg Konjac extract 1.2 mg glycosylceramides
Each serving contains 53 mg of konjac extract, providing 1.2 mg of glycosylceramides. The extract amount and the active amount are not the same.
500 mg Yuja extract Yuja fruit extract
Yuja fruit extract is included at 500 mg per serving.
A considered comparison
Look at the whole formula.
Compare the amounts, the ingredient forms and the daily cost.
| Daily ingredient | Advanced Liposomal NMNOne formula | Bought separatelyMatched-dose products |
|---|---|---|
| Liposomal NMN | 500 mg |
400 mg
USD 2.50per day
Other Liposomal NMN
View source9/27/26 |
| Liposomal CoQ10 | 100 mg |
100 mg
USD 0.88per day
View source9/26/26 |
| Spermidine | 1 mg |
1 mg
USD 0.17per day
View source9/27/26 |
| Total daily cost |
USD 2.00per day 9/27.26 |
USD 3.55per day |
USD · One-time purchase. Daily cost uses package price divided by days of supply at the compared dose. Excludes shipping and tax. Figures are rounded.
This comparison covers the listed ingredients. Ingredient forms and delivery systems may differ; review the source products for details.
Complete your AM ritual
Your wind-down by night.
Pair with Rest + Restore Magnesium to support relaxation and normal muscle function.*
How to use
A small moment.
Every morning.
Natural Yuja · Individual packets · Made in South Korea
-
Mix your packet
Add one packet to cool or room-temperature water.
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Make it your morning
Enjoy with breakfast as part of your daily routine.
-
Keep it consistent
Take it daily, ideally around the same time each morning.
Build around your routine.
Choose the support that fits your day.
The Haroutine Difference
Not Just Liposomal.
Liposomal NMN + CoQ10, with delivery built into the design.
-
Designed
to protect -
Absorption
in focus -
Validated Liposomal Ingredients
What sets Haroutine apart
Connected in Korea.
Our Korean platform brings formulation, Cryo-TEM imaging and manufacturing together—so we can look beyond the label.
See our validation standard
Cryo-TEM examines structure. Human absorption testing of Haroutine NMN is planned.
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