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Enhancing Skin Health

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This comprehensive article, published in the journal "Nutrients," delves into the critical roles vitamin C plays in maintaining skin health. The skin, being the largest organ of the body, serves as a vital barrier against environmental insults. It comprises two primary layers: the epidermal outer layer, which provides barrier function, and the inner dermal layer, ensuring strength and elasticity. Vitamin C is abundantly present in normal skin, aiding in collagen synthesis and offering antioxidant protection against UV-induced photodamage.

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Key Highlights

  1. Nutritional Importance for Skin Health: The article emphasizes the significance of nutrition, particularly micronutrients like vitamin C, for skin health and appearance. It discusses how vitamin C deficiency can lead to skin fragility and impaired wound healing.

  2. Vitamin C in Skin Layers: The skin's epidermis and dermis have varying concentrations of vitamin C. The epidermal layer, despite lacking blood vessels, shows higher vitamin C levels, indicating active accumulation from the circulation.

  3. Bioavailability and Uptake of Vitamin C: The skin's vitamin C content responds to plasma supply, with transport mediated by sodium-dependent vitamin C transporters (SVCTs). The article also explores the effectiveness of dietary supplementation versus topical application of vitamin C.

  4. Functions of Vitamin C in Skin: Vitamin C is crucial for collagen formation, acting as a co-factor for enzymes stabilizing the collagen molecule. It also plays a significant role in scavenging free radicals and protecting against oxidative damage, particularly in the epidermis.

  5. Topical Application of Vitamin C: The efficacy of topical vitamin C application depends on the formulation and the individual's plasma vitamin C status. The article discusses various formulations and their effectiveness in penetrating skin layers.

  6. Vitamin C and Skin Aging: The article notes that aged or photodamaged skin often has lower vitamin C levels. It suggests that maintaining optimal vitamin C levels might counteract some aging effects.

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"The central role for vitamin C and other antioxidants pertinent to the skin. The interdependence of vitamins E and C, and glutathione, in the scavenging of free radicals and regeneration of the reduced antioxidants, is shown. Vitamin E is in the lipid fraction of the cell, whereas vitamin C and glutathione are water-soluble and present in the cytosol."

Implications for Liposomal Vitamin C

The article's findings support the benefits of liposomal vitamin C for skin health. Liposomal encapsulation can enhance the bioavailability and uptake of vitamin C, potentially offering more effective skin nourishment and protection. This could be particularly beneficial in topical applications, where liposomal vitamin C might better penetrate skin layers and deliver its antioxidant and collagen-boosting benefits more efficiently.


The article by Pullar, Carr, and Vissers provides a detailed insight into the multifaceted roles of vitamin C in skin health, highlighting its importance in collagen synthesis, antioxidant protection, and overall skin integrity. It underscores the potential of liposomal vitamin C in enhancing these benefits, making it a valuable component in skincare and nutrition.

Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8), 866.

Enhancing Skin Health