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Lock In Vitamin C Goodness, Longer

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The study aimed to compare the concentrations of ascorbate (vitamin C) in plasma and white blood cells (WBCs) after oral administration of liposomal vitamin C versus traditional vitamin C in powder form. It also analyzed the effect of hydrocortisone on ascorbate intake by cells.

Key Findings

  1. Vitamin C and Immune Function: Vitamin C is crucial for immunity, protecting immune cells against oxidative stress. It enhances antibody production, improves macrophage function, increases interferon production, and promotes the maturation of T-cells and B-lymphocytes.

  2. Liposomal Vitamin C vs. Traditional Vitamin C: The study found that liposomal vitamin C results in longer retention of ascorbate in blood compared to non-encapsulated forms. It also showed faster intake by cells and a 50% larger area under the curve (AUC) for liposomal formulation.

  3. Effect of Hydrocortisone: Hydrocortisone, when administered with vitamin C supplementation, increased the transport of ascorbate into white blood cells, resulting in higher intracellular ascorbic acid concentrations.

Study Design

The study involved five subjects and followed a rigorous protocol, including a washout period, different supplementation phases, and blood sample analysis for ascorbate concentrations.


  • Plasma Vitamin C: Maximum concentration of ascorbate in plasma was achieved 2 hours after intake of non-encapsulated ascorbate and 4 hours for liposomal ascorbate.
  • White Blood Cells: Liposomal supplementation led to a faster and higher increase in ascorbate levels in WBCs compared to non-encapsulated forms.
  • Hydrocortisone's Impact: Hydrocortisone significantly enhanced the uptake of ascorbate by cells, both for liposomal and non-encapsulated forms.


The study supports the benefits of liposomal vitamin C in terms of better retention and faster cellular uptake compared to non-encapsulated forms. Additionally, hydrocortisone appears to enhance the effectiveness of vitamin C supplementation.

Nina Mikirova1; Tom Levy2; Ronald Hunninghake1. "The Levels of Ascorbic Acid in Blood and Mononuclear Blood Cells after Oral Liposome-Encapsulated and Oral Non-Encapsulated Vitamin C Supplementation Taken Without and With IV Hydrocortisone." International Society for Orthomolecular Medicine, [Year],

Lock In Vitamin C Goodness, Longer