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More Vitamin C Doesn’t Always Mean Better

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  • Traditional supplement routines may not lead to optimal absorption, even with higher doses.

  • A National Library of Medicine article examines the effectiveness of liposomal vitamin C against non-liposomal and intravenous forms.

  • Liposomal vitamin C proved to enhance absorption in comparison to non-liposomal intake but less than intravenous intake of vitamin C.

  • The study suggests that encapsulating vitamin C in liposomes is vital to preventing nutrient breakdown.

  • The groundbreaking formulation of vitamin C offers more opportunities to enjoy the full benefits of this essential nutrient without compromising quality.

In the realm of nutritional science, vitamin C has long been celebrated for its potent antioxidant properties, immune system support, and vital role in collagen synthesis. However, not all forms of vitamin C supplementation are created equal. Traditional oral supplementation has been challenged by issues of bioavailability and efficacy, particularly when compared to the more direct intravenous administration. A groundbreaking study sheds light on an innovative solution: the encapsulation of vitamin C in liposomes. This article explores the findings of this research, demonstrating the superior benefits of liposomal vitamin C over both traditional oral forms and intravenous methods in certain aspects.

A Closer Look At Vitamin C Intake:

Just when you think you’ve got your supplement routine down, you come to find out that your body might not be absorbing it all. Taking a higher dose doesn’t exactly solve that problem either. An article published by the National Library of Medicine compares the effectiveness of liposomal vitamin C to both non-liposomal and intravenous forms.

Traditional vs. Liposomal Vitamin C: A Comparative Insight

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The study in question delved into the efficacy of oral delivery of vitamin C encapsulated in liposomes. Participants were administered vitamin C through different methods: oral placebo, unencapsulated oral, liposomal oral, and intravenous. The results were telling; liposomal vitamin C achieved circulating concentrations higher than unencapsulated oral forms but slightly less than intravenous administration. However, when it came to protecting against oxidative stress induced by ischemia-reperfusion, liposomal vitamin C was on par with its intravenous counterpart.

Why Liposomal Vitamin C Stands Out

Liposomes are microscopic, spherical vesicles that can encapsulate nutrients, enhancing their delivery and absorption in the body. Here's why liposomal vitamin C presents a significant advancement:

  • Enhanced Bioavailability: The study confirmed that liposomal encapsulation improves vitamin C's bioavailability compared to traditional oral forms. This means more vitamin C is available for your body to use effectively.
  • Comparable to Intravenous Administration: While intravenous delivery achieves the highest circulating concentrations, liposomal vitamin C is not far behind. It offers a practical and less invasive alternative with similar benefits, especially in combating oxidative stress.
  • Protection Against Oxidative Stress: Oxidative stress can lead to numerous health issues, including inflammation and chronic diseases. The study illustrated that liposomal vitamin C effectively mitigates oxidative stress following an ischemia-reperfusion injury, similar to intravenous administration.

The Practical Implications

The implications of these findings are vast for both scientific research and clinical application. For individuals seeking enhanced immune support, improved skin health, or faster recovery from physical stress, liposomal vitamin C offers a promising solution. It bridges the gap between the convenience of oral supplements and the efficacy of intravenous administration. Furthermore, for older adults or those unable to receive intravenous treatments, liposomal vitamin C represents a breakthrough in accessible and effective supplementation.


National Library of Medicine. “Liposomal-Encapsulated Ascorbic Acid: Influence on Vitamin c Bioavailability and Capacity to Protect against Ischemia–Reperfusion Injury.” National Center for Biotechnology Information, 20 June 2016,

More Vitamin C Doesn’t Always Mean Better